Inter, El Clasico and more - the games Messi will miss with broken arm
The Argentina superstar scored Barca's second with a gorgeous 20-yard finish after a swift breakaway in the 12th minute, but he fell awkwardly soon after in a coming together with Sevilla's Franco Vazquez.
He was given medical attention for several minutes on the touchline, with Barca's trainers putting a significant amount of strapping around his right elbow.
But he was unable to continue and Barca confirmed shortly after full-time that he had suffered a broken arm, ruling him out for three weeks.
[INJURY NEWS] Tests carried out on the first team player Leo Messi have confirmed that he has a fracture of the radial bone in his right arm. He will be out for approximately three weeks. #FuerzaLeo pic.twitter.com/kpNcspnfqo
— FC Barcelona (@FCBarcelona) October 20, 2018
Below are the games he could potentially miss...
Barcelona v Inter - Champions League, October 24
Ernesto Valverde's men return to European action on Wednesday having won their first two Group B outings, though Inter - who also have a maximum six points - will surely provide a real examination of Barca, particularly without their talisman.
Barcelona v Real Madrid - LaLiga, October 28
Undoubtedly the biggest game Messi will miss is El Clasico next Sunday. Regardless of their Champions League encounter with Viktoria Plzen, Madrid will travel to Camp Nou in a desperate mood after suffering three defeats in their last four LaLiga outings. Reports say it is do or die for Julen Lopetegui - with Messi set to miss this fixture for the first time in 11 years, has the coach just been handed his greatest lifeline?
Cultural Leonesa v Barcelona - Copa del Rey, October 31
Barcelona begin their Copa del Rey defence at the end of the month, though the absence of Messi should not prove too much of an issue given they face third-tier side Cultural Leonesa. Even if they were to suffer a shock defeat, they will have a second leg in December to make amends.
7 - FC Barcelona won against Cultural Leonesa by an aggregate result of 7-0 in their only previous meeting in Spanish Cup (season 2009-10), with @_Pedro17_ scoring three goals. Memory. pic.twitter.com/f4ypZxny1w
— OptaJose (@OptaJose) October 19, 2018
Rayo Vallecano v Barcelona - LaLiga, November 3
Providing Rayo do not enjoy a significant upturn in the next two weeks, Barca again should be able to cope without Messi at Vallecas, where they ran out 5-1 winners on their last visit in March 2016. The five-time Ballon d'Or winner did net a hat-trick on that occasion, however.
Inter v Barcelona - Champions League, November 6
It remains to be seen how Barca's Champions League group looks ahead of their trip to San Siro, but there can be little doubt that this will be their trickiest away match before the knockout phase.
Barcelona v Real Betis - LaLiga, November 11
Given Messi has been given an approximate recovery time of three weeks, there is every chance he could also miss the visit of Betis, precisely 21 days after suffering his injury and just before the next international break. Nevertheless, the Andalusian club have not won at Camp Nou in any competition since August 2005.