Serie A official line-ups: Napoli vs. Pisa
Napoli make changes against Pisa, but stick with Kevin De Bruyne, Scott McTominay and Rasmus Hojlund, hoping to go clear at the top of Serie A.
It kicks off at the Stadio Diego Armando Maradona at 19.45 UK time (18.45 GMT).
You can follow all the build-up and action as it happens on the Liveblog.
The match will be shown live on TNT Sports 1 and DAZN in the UK and Ireland. Fans in the USA can watch it on Paramount+.
It is only Week 4, yet the reigning Champions of Italy already have the opportunity to go clear at the top of the table as the only remaining team with a 100 per cent record.
Antonio Conte must also balance out the effects of the draining midweek 2-0 Champions League defeat to Manchester City, which was played for over an hour down to 10 men because of the Giovanni Di Lorenzo red card.
There is squad rotation to a degree, as Alex Meret, Mathias Olivera, Eljif Elmas and Billy Gilmour all step in.
However, the big guns remain with De Bruyne, McTominay and Hojlund leading the way, as Romelu Lukaku will be out until December.
Pisa opened their first Serie A season in three decades by holding Atalanta 1-1, but followed that with narrow 1-0 defeats to Roma and Udinese.
Coach Alberto Gilardino suffered a painful blow in training this weekend when Calvin Stengs pulled up with a suspected adductor strain, and could be out for a while.
Idrissa Touré is absent because his wife went into labour, and Daniel Denoon is injured, with Juan Cuadrado only fit for the bench.
Giovanni Bonfanti, on loan from Atalanta, is given his first start in a more advanced role, with ex-Napoli defender Raul Albiol in the squad too.
Napoli vs. Pisa line-ups
Napoli: Meret; Di Lorenzo, Beukema, Buongiorno, Olivera; Gilmour; Politano, Elmas, De Bruyne, McTominay; Hojlund
Pisa: Semper; Canestrelli, Caracciolo, Lusuardi; Leris, Akinsanmiro, Aebischer, Marin, Bonfanti; Moreo, Nzola