Serie A official Week 25 line-ups: Pisa vs. Milan
Milan look to Christopher Nkunku, Ruben Loftus-Cheek, Luka Modric and Adrien Rabiot for their trip to Pisa, who are under new coach Oscar Hiljemark.
It kicks off at the Cetilar Arena at 19.45 GMT (20.45 CET).
You can follow all the build-up and action as it happens on the Liveblog.
The Rossoneri rested last weekend, as with San Siro out of action for the Winter Olympics opening ceremony, their match with Como has been rescheduled for February 18.
With that in mind, Max Allegri rotates the squad to rest some players for midweek, as Rafael Leao and Christian Pulisic are carrying knocks.
Alexis Saelemaekers and long-term absentee Santiago Gimenez are on the treatment table.
Instead, Nkunku leads the attack with support from Loftus-Cheek, Rabiot and Modric, while Zachary Athekame gets a rare start out wide.
Pisa are rock bottom of the Serie A table with just one win in their opening 24 games.
That record saw them sack Alberto Gilardino and bring in former Elfsborg coach Hiljemark, who at age 33 is younger than several of the Milan players.
He is no stranger to Italian football, having played for Genoa and Palermo as recently as 2019.
Hiljemark made his debut with a 0-0 draw against fellow strugglers Hellas Verona.
Marius Marin is suspended, with both goalkeepers Simone Scuffet and Adrian Semper injured, so 37-year-old Brazilian Nicolas has to step in for his first Serie A appearance since October 2020.
Also out of action are Raul Albiol, Daniel Denoon and Isak Vural.
The club bolstered the squad in January with players like Rosen Bozhinov, Samuel Iling-Junior, Felipe Loyola, Michel Aebischer, Filip Stojlkovic and Rafiu Durosinmi.
Pisa vs. Milan line-ups
Pisa: Nicolas; Canestrelli, Caracciolo, Bozhinov; Touré, Aebischer, Loyola, Angori; Tramoni, Stojilkovic, Moreo
Milan: Maignan; Tomori, Gabbia, Pavlovic; Athekame, Fofana, Modric, Rabiot, Bartesaghi; Loftus-Cheek, Nkunku